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Functional and phenotypic heterogeneity of Th17 cells in health and disease

Bystrom, J; Clanchy, FI; Taher, TE; Al-Bogami, M; Ong, VH; Abraham, DJ; Williams, RO; (2018) Functional and phenotypic heterogeneity of Th17 cells in health and disease. European Journal of Clinical Investigation , Article e13032. 10.1111/eci.13032. (In press).

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Abstract

Th17 cells have non-redundant roles in maintaining immunity, particularly at mucosal surfaces. These roles are achieved principally through the production of cytokines and the recruitment of other immune cells to maintain the integrity of mucosal barriers and prevent the dissemination of microorganisms. Th17 cells are heterogeneous and exhibit a considerable degree of plasticity. This allows these cells to respond to changing environmental challenges. In addition to their protective role in immunity, studies involving animal models, patient data, genome wide association studies and clinical trials targeting IL-17 for treatment of patients have provided evidence that Th17 cells also play pro-inflammatory roles in chronic autoimmune diseases. Less clear, however, are triggers that initiate or perpetuate Th17 responses to promote chronic inflammation and autoimmunity, and the divergent effects of tumour necrosis factor alpha blockade on Th17 cells in patient subgroups. Th17 cells also stimulate B lymphocytes and enhance humoral immunity by inducing polyclonal activation of autoreactive B lymphocytes, leading to autoantibody production. In addition, some pathogenic bacterial species can change Th17 cell phenotype and responses. These effects are implicated in promoting pathogenic roles for Th17 cells in autoimmune diseases. This article provides an overview of the distinct roles Th17 cells can play in maintaining immunity at mucosal surfaces and in skin mucosa and how this is linked to chronic inflammation in autoimmune rheumatic diseases. This article is protected by copyright. All rights reserved.

Type: Article
Title: Functional and phenotypic heterogeneity of Th17 cells in health and disease
Location: England
DOI: 10.1111/eci.13032
Publisher version: https://doi.org/10.1111/eci.13032
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Th17 cells, auto-immunity, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, systemic sclerosise
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/10058161
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