UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Heritability of the Effective Connectivity in the Resting-State Default Mode Network

Xu, J; Yin, X; Ge, H; Han, Y; Pang, Z; Liu, B; Liu, S; (2017) Heritability of the Effective Connectivity in the Resting-State Default Mode Network. Cereb Cortex , 27 (12) pp. 5626-5634. 10.1093/cercor/bhw332. Green open access

[img]
Preview
Text
Friston_Genetic_controls_DMN.pdf - ["content_typename_Accepted version" not defined]

Download (1MB) | Preview

Abstract

The default mode network (DMN) is thought to reflect endogenous neural activity, which is considered as one of the most intriguing phenomena in cognitive neuroscience. Previous studies have found that key regions within the DMN are highly interconnected. Here, we characterized the genetic influences on causal or directed information flow within the DMN during the resting state. In this study, we recruited 46 pairs of twins and collected fMRI imaging data using a 3.0 T scanner. Dynamic causal modeling was conducted for each participant, and a structural equation model was used to calculate the heritability of DMN in terms of its effective connectivity. Model comparison favored a full-connected model. Structural equal modeling was used to estimate the additive genetics (A), common environment (C) and unique environment (E) contributions to variance for the DMN effective connectivity. The ACE model was preferred in the comparison of structural equation models. Heritability of DMN effective connectivity was 0.54, suggesting that the genetic made a greater contribution to the effective connectivity within DMN. Establishing the heritability of default-mode effective connectivity endorses the use of resting-state networks as endophenotypes or intermediate phenotypes in the search for the genetic basis of psychiatric or neurological illnesses.

Type: Article
Title: Heritability of the Effective Connectivity in the Resting-State Default Mode Network
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cercor/bhw332
Publisher version: http://dx.doi.org/10.1093/cercor/bhw332
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: DCM, default mode network, effective connectivity, heritability, resting-state fMRI, Adolescent, Brain, Brain Mapping, Female, Gene-Environment Interaction, Humans, Inheritance Patterns, Magnetic Resonance Imaging, Male, Models, Genetic, Models, Statistical, Neural Pathways, Rest, Twins, Dizygotic, Twins, Monozygotic, Young Adult
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/10057802
Downloads since deposit
7Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item