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A review of psychiatric co-morbidity described in genetic and immune mediated movement disorders

Peall, KJ; Lorentzos, MS; Heyman, I; Tijssen, MAJ; Owen, MJ; Dale, RC; Kurian, MA; (2017) A review of psychiatric co-morbidity described in genetic and immune mediated movement disorders. Neuroscience and Biobehavioral Reviews , 80 pp. 23-35. 10.1016/j.neubiorev.2017.05.014. Green open access

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Abstract

Psychiatric symptoms are an increasingly recognised feature of movement disorders. Recent identification of causative genes and autoantibodies has allowed detailed analysis of aetiologically homogenous subgroups, thereby enabling determination of the spectrum of psychiatric symptoms in these disorders. This review evaluates the incidence and type of psychiatric symptoms encountered in patients with movement disorders. A broad spectrum of psychiatric symptoms was identified across all subtypes of movement disorder, with depression, generalised anxiety disorder and obsessive-compulsive disorder being most common. Psychosis, schizophrenia and attention deficit hyperactivity disorder were also identified, with the psychiatric symptoms often predating onset of the motor disorder. The high incidence of psychiatric symptoms across such a wide range of movement disorders suggests a degree of common or overlapping pathogenic mechanisms. Our review demonstrates the need for increased clinical awareness of such co-morbidities, which should facilitate early neuropsychiatric intervention and allied specialist treatment for patients.

Type: Article
Title: A review of psychiatric co-morbidity described in genetic and immune mediated movement disorders
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neubiorev.2017.05.014
Publisher version: https://doi.org/10.1016/j.neubiorev.2017.05.014
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Movement Disorders, Genetics, Immune mediated, Psychiatric phenotype
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/10057593
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