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Harvesting the promise of AOPs: An assessment and recommendations

Carusi, A; Davies, M; De Grandis, G; Escher, B; Hodges, G; Leung, K; Whelan, M; ... Ankley, G; + view all (2018) Harvesting the promise of AOPs: An assessment and recommendations. Science of the Total Environment , 628-9 pp. 1542-1556. 10.1016/j.scitotenv.2018.02.015. Green open access

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Abstract

The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we identify and describe those stakeholders who currently—or in the future—could benefit from the application of the AOP framework and knowledge to specific problems. We also summarize the challenges faced in implementing pathway-based approaches such as the AOP framework in biological sciences, and provide a series of recommendations to meet critical needs to ensure further progression of the framework as a useful, sustainable and dependable tool supporting assessments of both human health and the environment. Although the AOP concept has the potential to significantly impact the organization and interpretation of biological information in a variety of disciplines/applications, this promise can only be fully realized through the active engagement of, and input from multiple stakeholders, requiring multi-pronged substantive long-term planning and strategies.

Type: Article
Title: Harvesting the promise of AOPs: An assessment and recommendations
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.scitotenv.2018.02.015
Publisher version: http://dx.doi.org/10.1016/j.scitotenv.2018.02.015
Language: English
Additional information: © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Toxicology, Adverse outcomes pathways, Risk assessment, Environmental health, Chemical management, Social, ethical and legal aspects
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > STEaPP
URI: https://discovery.ucl.ac.uk/id/eprint/10056645
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