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Effect of copolymer composition on particle morphology and release behavior in vitro using progesterone

Zhang, Y; Shams, T; Harker, AH; Parhizkar, M; Edirisinghe, M; (2018) Effect of copolymer composition on particle morphology and release behavior in vitro using progesterone. Materials & Design , 159 pp. 57-67. 10.1016/j.matdes.2018.08.024. Green open access

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Abstract

This study was aimed at improving dissolution rate and sustained release of progesterone by varying copolymer composition and polymer: drug ratio of PLGA. Drug-loaded particles were prepared using electrohydrodynamic atomization. The effects of polymer: drug ratio and copolymer composition on particle properties and in vitro drug-release profile were investigated. The physical form of the generated particles was determined via X-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FTIR). Drug release in vitro was found to be dependent on copolymer composition, where the release rate increased with decreased lactide content of PLGA. Particles produced with solutions of copolymer (75:25) had elongated shapes. In general, the obtained results indicated that the prepared microparticles were ideal carriers for oral administration of progesterone offering great potential to improve the dissolution rate of drugs that suffer from low aqueous solubility.

Type: Article
Title: Effect of copolymer composition on particle morphology and release behavior in vitro using progesterone
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.matdes.2018.08.024
Publisher version: https://doi.org/10.1016/j.matdes.2018.08.024
Language: English
Additional information: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Electrohydrodynamic, Progesterone, Mathematical modelling, Drug delivery system
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: http://discovery.ucl.ac.uk/id/eprint/10056446
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