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Tau Mutations Serve as a Novel Risk Factor for Cancer

Rossi, G; Redaelli, V; Contiero, P; Fabiano, S; Tagliabue, G; Perego, P; Benussi, L; ... Tagliavini, F; + view all (2018) Tau Mutations Serve as a Novel Risk Factor for Cancer. Cancer Research , 78 (13) pp. 3731-3739. 10.1158/0008-5472.CAN-17-3175.

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Abstract

In addition to its well-recognized role in neurodegeneration, tau participates in maintenance of genome stability and chromosome integrity. In particular, peripheral cells from patients affected by frontotemporal lobar degeneration carrying a mutation in tau gene (genetic tauopathies), as well as cells from animal models, show chromosome numerical and structural aberrations, chromatin anomalies, and a propensity toward abnormal recombination. As genome instability is tightly linked to cancer development, we hypothesized that mutated tau may be a susceptibility factor for cancer. Here we conducted a retrospective cohort study comparing cancer incidence in families affected by genetic tauopathies to control families. In addition, we carried out a bioinformatics analysis to highlight pathways associated with the tau protein interactome. We report that the risk of developing cancer is significantly higher in families affected by genetic tauopathies, and a high proportion of tau protein interactors are involved in cellular processes particularly relevant to cancer. These findings disclose a novel role of tau as a risk factor for cancer, providing new insights in the various pathologic roles of mutated tau.

Type: Article
Title: Tau Mutations Serve as a Novel Risk Factor for Cancer
DOI: 10.1158/0008-5472.CAN-17-3175
Publisher version: http://doi.org/10.1158/0008-5472.CAN-17-3175
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: neurodegeneration; cancer; tau; MAPT; mutation; risk factor; epidemiology; bioinformatics
URI: http://discovery.ucl.ac.uk/id/eprint/10056116
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