UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Inter‐cortical modulation from premotor to motor plasticity

Huang, Y-Z; Chen, R-S; Fong, P-Y; Rothwell, JC; Chuang, W-L; Weng, Y-H; Lin, W-Y; (2018) Inter‐cortical modulation from premotor to motor plasticity. The Journal of Physiology , 596 (17) pp. 4207-4217. 10.1113/JP276276. Green open access

[img]
Preview
Text (Article)
Rothwell_Inter-cortical modulation from premotor to motor plasticity_AAM.pdf - ["content_typename_Accepted version" not defined]

Download (1MB) | Preview
[img]
Preview
Text (Supplement no. 1)
Rothwell_Inter-cortical modulation from premotor to motor plasticity_Supp_AAM.pdf - ["content_typename_Accepted version" not defined]

Download (437kB) | Preview
[img]
Preview
Text (Supplement no. 2)
Rothwell_Inter-cortical modulation from premotor to motor plasticity_Supp2_AAM.pdf - ["content_typename_Accepted version" not defined]

Download (120kB) | Preview
[img]
Preview
Text (Supplement no. 3)
Rothwell_Inter-cortical modulation from premotor to motor plasticity_Supp3_AAM.pdf - ["content_typename_Accepted version" not defined]

Download (120kB) | Preview
[img]
Preview
Text (Supplement no. 4)
Rothwell_Inter-cortical modulation from premotor to motor plasticity_Supp4_AAM.pdf - ["content_typename_Accepted version" not defined]

Download (343kB) | Preview
[img]
Preview
Text (Supplement no. 5)
Rothwell_Inter-cortical modulation from premotor to motor plasticity_Supp5_AAM.pdf - ["content_typename_Accepted version" not defined]

Download (285kB) | Preview

Abstract

Primary motor cortex (M1) plasticity is known to be influenced by the excitability and prior activation history of M1 itself. However, little is known about how its plasticity is influenced by other areas of the brain. In the present study on humans of either sex who were known to respond to theta burst stimulation from previous studies, we found plasticity of M1 could be modulated by suppressing the premotor cortex with the theta burst form of repetitive transcranial magnetic stimulation. Motor plasticity was distorted and disappeared 30 min and 120 min, respectively, after premotor excitability was suppressed. Further evaluation revealed that such changes in motor plasticity were associated with impaired learning of a simple motor task. We postulate that the premotor cortex modulates the amount of plasticity within M1 through heterosynaptic metaplasticity, and that this may impact on learning of a simple motor task previously shown to be directly affected by M1 plasticity. The present results provide an insight into how the brain physiologically coordinates two different areas to bring them into a functional network. Furthermore, such concepts could be translated into therapeutic approaches for diseases with aberrant plasticity.

Type: Article
Title: Inter‐cortical modulation from premotor to motor plasticity
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1113/JP276276
Publisher version: https://doi.org/10.1113/JP276276
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: motor practice, plasticity, theta burst stimulation (TBS), transcranial magnetic stimulation (TMS)
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/10056014
Downloads since deposit
39Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item