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Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity

Chen, J-C; Macerollo, A; Sadnicka, A; Lu, M-K; Tsai, C-H; Korlipara, P; Bhatia, K; ... Edwards, MJ; + view all (2018) Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity. Clinical Neurophysiology , 129 (9) pp. 1947-1954. 10.1016/j.clinph.2018.05.028. Green open access

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Abstract

OBJECTIVE: Previous electrophysiological and psychophysical tests have suggested that somatosensory integration is abnormal in dystonia. Here, we hypothesised that this abnormality could relate to a more general deficit in pre-attentive error/deviant detection in patients with dystonia. We therefore tested patients with dystonia and healthy subjects using a mismatch negativity paradigm (MMN), where evoked potentials generated in response to a standard repeated stimulus are subtracted from the responses to a rare “odd ball” stimulus. METHODS: We assessed MMN for somatosensory and auditory stimuli in patients with cervical dystonia and healthy age matched controls. RESULTS: We found a significant group ∗ oddball type interaction effect (F (1, 34) = 4.5, p = 0.04, ρ₁ = 0.63). A follow up independent t-test for sMMN data, showed a smaller sMMN amplitude in dystonic patients compared to controls (mean difference control-dystonia: −1.0 µV ± 0.3, p < 0.00, t = −3.1). However the amplitude of aMMN did not differ between groups (mean difference control-dystonia: −0.2 µV ± 0.2, p = 0.24, t = −1.2). We found a positive correlation between somatosensory MMN and somatosensory temporal discrimination threshold.CONCLUSION: These results suggest that pre-attentive error/deviant detection, specifically in the somatosensory domain, is abnormal in dystonia. This could underlie some previously reported electrophysiological and psychophysical abnormalities of somatosensory integration in dystonia. SIGNIFICANCE: One could hypothesize a deficit in pre-conscious orientation towards potentially salient signals might lead to a more conservative threshold for decision-making in dystonia.

Type: Article
Title: Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.clinph.2018.05.028
Publisher version: https://doi.org/10.1016/j.clinph.2018.05.028
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Mismatch negativity (MMN), Dystonia, Somatosensory integration
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/10056010
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