UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

What do monoamines do in pain modulation

Bannister, K; Dickenson, AH; (2016) What do monoamines do in pain modulation. Current Opinion in Supportive and Palliative Care , 10 (2) pp. 143-148. 10.1097/SPC.0000000000000207. Green open access

[img]
Preview
Text
emss-69185.pdf - ["content_typename_Accepted version" not defined]

Download (294kB) | Preview

Abstract

PURPOSE OF REVIEW: Here, we give a topical overview of the ways in which brain processing can alter spinal pain transmission through descending control pathways, and how these change in pain states. We link preclinical findings on the transmitter systems involved and discuss how the monoamines, noradrenaline, 5-hydroxytryptamine (5-HT), and dopamine, can interact through inhibitory and excitatory pathways. RECENT FINDINGS: Descending pathways control sensory events and the actions of the neurotransmitters noradrenaline and 5-HT in the dorsal horn of the spinal cord are chiefly implicated in nociception or antinociception according to the receptor that is activated. Abnormalities in descending controls effect central pain processing. Following nerve injury a noradrenaline-mediated control of spinal excitability is lost, whereas its restoration reduces neuropathic hypersensitivity. The story with 5-HT remains more complex because of the myriad of receptors that it can act upon; however the most recent findings support that facilitations may dominate over inhibitions. SUMMARY: The monoaminergic system can be manipulated to great effect in the clinic resulting in improved treatment outcomes and is the basis for the actions of the antidepressant drugs in pain. Looking to the future, prediction of treatment responses will possible by monitoring a form of inhibitory descending control for optimized pain relief.

Type: Article
Title: What do monoamines do in pain modulation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/SPC.0000000000000207
Publisher version: https://doi.org/10.1097/SPC.0000000000000207
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Monoamines, descending controls, noradrenergic pain inhibition, serotonergic pain facilitation, conditioned pain modulation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/10055872
Downloads since deposit
46Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item