UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Minimal clinically important worsening on the progressive supranuclear Palsy Rating Scale

Hewer, S; Varley, S; Boxer, AL; Paul, E; Williams, DR; AL-108-231 Investigators, ; (2016) Minimal clinically important worsening on the progressive supranuclear Palsy Rating Scale. Movement Disorders , 31 (10) pp. 1574-1577. 10.1002/mds.26694.

[img] Text
nihms839703.pdf - ["content_typename_Accepted version" not defined]
Access restricted to UCL open access staff

Download (51kB)

Abstract

BACKGROUND: Despite the widespread use of the Progressive Supranuclear Palsy Rating Scale (PSPRS), it is not known what change in this scale is meaningful for patients. METHODS: We analyzed data from a large clinical trial in PSP-Richardson's syndrome (AL-108-231) to calculate minimal clinically important worsening. This was defined as the difference in mean change of PSPRS in subjects rated "a little worse" and those rated "unchanged" on the Clinicians' Global Impression of Change Scale. A multivariate analysis using logistic regression assessed the relationship between clinical worsening, PSPRS, depression, and activities of daily living. RESULTS: The minimal clinically important worsening on the PSPRS was 5.7 points, corresponding to the mean decline over 6 months in the trial. Changes in activities of daily living and PSPRS were significantly associated with clinical worsening. CONCLUSIONS: Clinically meaningful change is measurable on the PSPRS over 6 months. © 2016 International Parkinson and Movement Disorder Society.

Type: Article
Title: Minimal clinically important worsening on the progressive supranuclear Palsy Rating Scale
Location: United States
DOI: 10.1002/mds.26694
Publisher version: https://doi.org/10.1002/mds.26694
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Minimal clinically important change (MCIC), progressive supranuclear palsy (PSP), progressive supranuclear palsy rating scale (PSPRS), Aged, Disease Progression, Female, Humans, Male, Middle Aged, Minimal Clinically Important Difference, Oligopeptides, Severity of Illness Index, Supranuclear Palsy, Progressive
URI: http://discovery.ucl.ac.uk/id/eprint/10055853
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item