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The Outcome of Dopamine Dysregulation Syndrome in Parkinson's Disease: A Retrospective Post Mortem Study

Barbosa, PM; Djamshidian, A; Lees, AJ; Warner, TT; (2018) The Outcome of Dopamine Dysregulation Syndrome in Parkinson's Disease: A Retrospective Post Mortem Study. Movement Disorders Clinical Practice 10.1002/mdc3.12671. (In press).

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Abstract

INTRODUCTION: We have performed a retrospective analysis of the frequency and relation to treatment of dopamine dysregulation syndrome (DDS) using the Queen Square Brain Bank (QSBB) database. METHODS: A search of the QSBB database for consecutive cases donated between 2005 to 2016 with a pathological diagnosis of Parkinson's disease was performed. RESULTS: DDS was present in 8.8% of cases, was more prevalent in males and associated with younger age of onset, longer disease duration and more dopa‐induced dyskinesias. Treatment approaches for DDS included: reduction of levodopa, reduction/cessation of DA and initiation of infusion therapies. DDS had completely resolved in just over half the patients. DA peak levodopa equivalent daily dose (LEDD) was higher in patients who failed to achieve remission. CONCLUSION: This is the first study to provide data on the course of DDS until death. Treatment strategies consisted mainly of reduction of dopaminergic treatment and despite the majority of patients showing some improvement, half remained symptomatic. Successful treatment was associated with a lower l‐dopa dosage at death.

Type: Article
Title: The Outcome of Dopamine Dysregulation Syndrome in Parkinson's Disease: A Retrospective Post Mortem Study
DOI: 10.1002/mdc3.12671
Publisher version: https://doi.org/10.1002/mdc3.12671
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Parkinson's disease, dopamine dysregulation syndrome, outcome, dopaminergic treatment
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/10054782
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