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Fibrotic Hypersensitivity Pneumonitis: Key Issues in Diagnosis and Management

Kouranos, V; Jacob, J; Nicholson, A; Renzoni, E; (2017) Fibrotic Hypersensitivity Pneumonitis: Key Issues in Diagnosis and Management. Journal of Clinical Medicine , 6 (6) , Article 62. 10.3390/jcm6060062. Green open access

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Abstract

The diagnosis of hypersensitivity pneumonitis (HP) relies on the clinical evaluation of a number of features, including a history of significant exposure to potentially causative antigens, physical examination, chest CT scan appearances, bronchoalveolar lavage lymphocytosis, and, in selected cases, histology. The presence of fibrosis is associated with higher morbidity and mortality. Differentiating fibrotic HP from the idiopathic interstitial pneumonias can be a challenge. Furthermore, even in the context of a clear diagnosis of fibrotic HP, the disease behaviour can parallel that of idiopathic pulmonary fibrosis in a subgroup, with inexorable progression despite treatment. We review the current knowledge on the diagnosis, management, and prognosis of HP with particular focus on the fibrotic phenotype.

Type: Article
Title: Fibrotic Hypersensitivity Pneumonitis: Key Issues in Diagnosis and Management
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/jcm6060062
Publisher version: https://doi.org/10.3390/jcm6060062
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Keywords: fibrotic hypersensitivity pneumonitis; idiopathic pulmonary fibrosis; diagnosis; prognosis
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/10054272
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