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Renal allograft survival rates in kidneys initially declined for paediatric transplantation

Marlais, M; Pankhurst, L; Martin, K; Mumford, L; Tizard, EJ; Marks, SD; (2018) Renal allograft survival rates in kidneys initially declined for paediatric transplantation. Pediatric Nephrology , 33 (9) pp. 1609-1616. 10.1007/s00467-018-3969-4. Green open access

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Abstract

BACKGROUND: The outcome of organs which have been declined for paediatric recipients is not known. This study aimed to determine the outcome of kidneys initially declined for paediatric recipients and establish renal allograft survival in kidneys that were eventually transplanted. METHODS: Data were obtained from the UK Transplant Registry for all donation after brain death (DBD) kidneys offered and declined to paediatric recipients (< 18 years) in the UK from 2009 to 2014. RESULTS: Eighty-two percent (503/615) of kidneys initially declined for paediatric transplantation were eventually transplanted, 7% (46/615) of kidneys went to paediatric recipients and 62% (384/615) of kidneys went to adult (kidney only) recipients. The remainder were used for multiple organ transplants. In the 46 kidneys that went to paediatric recipients, 1 and 3-year renal allograft survivals were 89% (95% CI 75.8-95.3%) and 82% (95% CI 67.1-90.6%), respectively. In the 384 kidneys given to adult kidney-only recipients, 1 and 3-year renal allograft survivals were 96% (95% CI 93.5-97.6%) and 94% (95% CI 90.7-96.1%), respectively. Eighty-four percent of the 204 children who initially had an offer declined on their behalf were eventually transplanted and have a functioning graft at a median 3-year follow-up. CONCLUSIONS: This study reports acceptable short-term renal allograft survival in kidneys that were initially declined for paediatric recipients and subsequently transplanted. Evidence-based guidelines are required to ensure that the most appropriate kidneys are selected for paediatric recipients.

Type: Article
Title: Renal allograft survival rates in kidneys initially declined for paediatric transplantation
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00467-018-3969-4
Publisher version: http://dx.doi.org/10.1007/s00467-018-3969-4
Language: English
Additional information: © The Author(s) 2018. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Paediatric nephrology, Renal transplantation, Transplant outcomes
URI: http://discovery.ucl.ac.uk/id/eprint/10054220
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