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TaiNi: Maximizing research output whilst improving animals’ welfare in neurophysiology experiments

Jiang, Z; Huxter, JR; Bowyer, SA; Blockeel, AJ; Butler, J; Imtiaz, SA; Wafford, KA; ... Rodriguez-Villegas, E; + view all (2017) TaiNi: Maximizing research output whilst improving animals’ welfare in neurophysiology experiments. Scientific Reports , 7 , Article 8086. 10.1038/s41598-017-08078-8. Green open access

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Abstract

Understanding brain function at the cell and circuit level requires representation of neuronal activity through multiple recording sites and at high sampling rates. Traditional tethered recording systems restrict movement and limit the environments suitable for testing, while existing wireless technology is still too heavy for extended recording in mice. Here we tested TaiNi, a novel ultra-lightweight (<2 g) low power wireless system allowing 72-hours of recording from 16 channels sampled at ~19.5 KHz (9.7 KHz bandwidth). We captured local field potentials and action-potentials while mice engaged in unrestricted behaviour in a variety of environments and while performing tasks. Data was synchronized to behaviour with sub-second precision. Comparisons with a state-of-the-art wireless system demonstrated a significant improvement in behaviour owing to reduced weight. Parallel recordings with a tethered system revealed similar spike detection and clustering. TaiNi represents a significant advance in both animal welfare in electrophysiological experiments, and the scope for continuously recording large amounts of data from small animals.

Type: Article
Title: TaiNi: Maximizing research output whilst improving animals’ welfare in neurophysiology experiments
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41598-017-08078-8
Publisher version: https://doi.org/10.1038/s41598-017-08078-8
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://discovery.ucl.ac.uk/id/eprint/10054178
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