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Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice

Javaheri, B; Razi, H; Piles, M; de Souza, R; Chang, YM; Maric-Mur, I; Hopkinson, M; ... Pitsillides, AA; + view all (2018) Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis and Cartilage , 26 (6) pp. 807-817. 10.1016/j.joca.2018.03.008. Green open access

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Abstract

Objectives: Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and in both sexes of parental, control CBA mice to explore whether early divergence in tibial bone mass or shape are linked to emergent OA. // Method: We undertook detailed micro-CT comparisons of trabecular and cortical bone, multiple structural/architectural parameters and finite element modelling (FEM) of the tibia from male and female STR/Ort and CBA mice at 8–10 (pre-OA), 18–20 (OA onset) and 40 + weeks (advanced OA) of age. // Results: We found higher trabecular bone mass in female STR/Ort than in either OA-prone male STR/Ort or non-prone CBA mice. Cortical bone, as expected, showed greater cross-sectional area in male than female CBA, which surprisingly was reversed in STR/Ort mice. STR/Ort also exhibited higher cortical bone mass than CBA mice. Our analyses revealed similar tibial ellipticity, yet greater predicted resistance to torsion in male than female CBA mice. In contrast, male STR/Ort exhibited greater ellipticity than both female STR/Ort and CBA mice at specific cortical sites. Longitudinal analysis revealed greater tibia curvature and shape deviations in male STR/Ort mice that coincided with onset and were more pronounced in late OA. // Conclusion: Generalised higher bone mass in STR/Ort mice is more marked in non OA-prone females, but pre-OA divergence in bone shape is restricted to male STR/Ort mice in which OA develops spontaneously.

Type: Article
Title: Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.joca.2018.03.008
Publisher version: https://doi.org/10.1016/j.joca.2018.03.008
Language: English
Additional information: © 2018 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/)
Keywords: Osteoarthritis, Bone shape, STR/Ort, Pain, Gait
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/10054006
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