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Toward adaptive deep brain stimulation for dystonia

Piña-Fuentes, D; Beudel, M; Little, SJ; van Zijl, J; Elting, JW; Oterdoom, DLM; van Egmond, ME; ... Tijssen, MAJ; + view all (2018) Toward adaptive deep brain stimulation for dystonia. Journal of Neurosurgery , 45 (2) , Article E3. 10.3171/2018.5.FOCUS18155. Green open access

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Abstract

The presence of abnormal neural oscillations within the cortico-basal ganglia-thalamo-cortical (CBGTC) network has emerged as one of the current principal theories to explain the pathophysiology of movement disorders. In theory, these oscillations can be used as biomarkers and thereby serve as a feedback signal to control the delivery of deep brain stimulation (DBS). This new form of DBS, dependent on different characteristics of pathological oscillations, is called adaptive DBS (aDBS), and it has already been applied in patients with Parkinson’s disease. In this review, the authors summarize the scientific research to date on pathological oscillations in dystonia and address potential biomarkers that might be used as a feedback signal for controlling aDBS in patients with dystonia.

Type: Article
Title: Toward adaptive deep brain stimulation for dystonia
Open access status: An open access version is available from UCL Discovery
DOI: 10.3171/2018.5.FOCUS18155
Publisher version: http://doi.org/10.3171/2018.5.FOCUS18155
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: adaptive deep brain stimulation, dystonia, local field potentials, electromyography, low-frequency oscillations
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/10053866
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