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Complex mechanics of the heterogeneous extracellular matrix in cancer

Malandrino, A; Mak, M; Kamm, RD; Moeendarbary, E; (2018) Complex mechanics of the heterogeneous extracellular matrix in cancer. Extreme Mechanics Letters , 21 pp. 25-34. 10.1016/j.eml.2018.02.003. Green open access

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Abstract

The extracellular matrix (ECM) performs many critical functions, one of which is to provide structural and mechanical integrity, and many of the constituent proteins have clear mechanical roles. The composition and structural characteristics of the ECM are widely variable among different tissues, suiting diverse functional needs. In diseased tissues, particularly solid tumors, the ECM is complex and influences disease progression. Cancer and stromal cells can significantly influence the matrix composition and structure and thus the mechanical properties of the tumor microenvironment (TME). In this review, we describe the interactions that give rise to the structural heterogeneity of the ECM and present the techniques that are widely employed to measure ECM properties and remodeling dynamics. Furthermore, we review the tools for measuring the distinct nature of cell–ECM interactions within the TME.

Type: Article
Title: Complex mechanics of the heterogeneous extracellular matrix in cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.eml.2018.02.003
Publisher version: https://doi.org/10.1016/j.eml.2018.02.003
Language: English
Additional information: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/10053792
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