Hauser, TU;
Will, G-J;
Dubois, M;
Dolan, RJ;
(2019)
Annual Research Review: Developmental computational psychiatry.
Journal of Child Psychology and Psychiatry
, 60
(4)
pp. 412-426.
10.1111/jcpp.12964.
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Abstract
Most psychiatric disorders emerge during childhood and adolescence. This is also a period that coincides with the brain undergoing substantial growth and reorganisation. However, it remains unclear how a heightened vulnerability to psychiatric disorder relates to this brain maturation. Here, we propose ‘developmental computational psychiatry’ as a framework for linking brain maturation to cognitive development. We argue that through modelling some of the brain's fundamental cognitive computations, and relating them to brain development, we can bridge the gap between brain and cognitive development. This in turn can lead to a richer understanding of the ontogeny of psychiatric disorders. We illustrate this perspective with examples from reinforcement learning and dopamine function. Specifically, we show how computational modelling deepens an understanding of how cognitive processes, such as reward learning, effort learning, and social learning might go awry in psychiatric disorders. Finally, we sketch the promises and limitations of a developmental computational psychiatry.
| Type: | Article |
|---|---|
| Title: | Annual Research Review: Developmental computational psychiatry |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jcpp.12964 |
| Publisher version: | https://doi.org/10.1111/jcpp.12964 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Developmental computational psychiatry, reinforcement learning, prediction error, dopamine, self‐esteem, apathy, motivation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053684 |
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