Ravagli, E;
Severi, S;
(2018)
Optical and Electrical Characterization of Biocompatible Polymeric Lines for Hemodialysis Applications.
Materials
, 11
(3)
, Article 438. 10.3390/ma11030438.
Preview |
Text
Optical and Electrical Characterization of Biocompatible Polymeric Lines for Hemodialysis Applications.pdf - Published Version Download (2MB) | Preview |
Abstract
During hemodialysis (HD), blood is circulated through an extracorporeal tubing system (bloodline) made of medical-grade polymeric material. Sensors of various types that do not come into contact with blood (optical, electromagnetic, etc.) are applied directly across the bloodline for clinical purposes and for therapy customization. Thus, a detailed knowledge of the bloodline’s physical properties is useful for the development of next-generation HD sensors. In this work, we performed a novel comparative analysis of the materials used by the manufacturers of the bloodlines. We focused on signals and characterization techniques matching those of the abovementioned sensors; consequently, this is an application-specific study of the optical and electrical characterization of bloodline material. Such properties are analyzed and compared for bloodlines from seven different manufacturers by optical absorbance spectroscopy and electrical impedance spectroscopy (EIS). Absorbance spectrum measurements are carried out in the VIS-NIR range. Absorbance spectra are pre-processed and data from both types of analyses are normalized with respect to sample thickness. Optical analysis shows that all bloodlines except one have similarly shaped spectra with slight quantitative differences. In all optical spectra, we find a decreasing trend of specific absorption from 0.14 mm−1 at 400 nm to 0.06 mm−1 at 1000 nm, with an absorption peak at 915 nm. In one case, a large absorption peak centered at ≃600 nm is found. Electrical analysis shows that all bloodlines have the electrical properties of a constant-phase element (CPE), with statistically significant differences in parameters’ values. Estimation of electrical CPE parameters for all bloodline returns a range of 0.942–0.957 for parameter n and a range of 12.41–16.64 for parameter Q0’. In conclusion, we find that, although some statistically significant differences are present, bloodlines from a representative group of manufacturers share similar electrical and optical properties. Therefore, contactless sensing devices developed for HD will work on different bloodlines if a simple recalibration is performed.
| Type: | Article |
|---|---|
| Title: | Optical and Electrical Characterization of Biocompatible Polymeric Lines for Hemodialysis Applications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/ma11030438 |
| Publisher version: | https://doi.org/10.3390/ma11030438 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Technology, Materials Science, Multidisciplinary, Materials Science, hemodialysis, biopolymer, bloodline, electrical impedance, optical absorbance, CONSTANT PHASE ELEMENT, BLOOD-VOLUME, PRESSURE SIGNALS, CARDIAC SIGNAL, MACHINE, HYPOTENSION, DEVICE, MONITOR |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053232 |
Archive Staff Only
 |
View Item |
