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Insight into Two ABC Transporter Families Involved in Lantibiotic Resistance

Clemens, R; Zaschke-Kriesche, J; Khosa, S; Smits, SHJ; (2017) Insight into Two ABC Transporter Families Involved in Lantibiotic Resistance. Frontiers in Molecular Biosciences , 4 , Article 91. 10.3389/fmolb.2017.00091. Green open access

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Abstract

Antimicrobial peptides, which contain (methyl)-lanthionine-rings are called lantibiotics. They are produced by several Gram-positive bacteria and are mainly active against these bacteria. Although these are highly potent antimicrobials, some human pathogenic bacteria express specific ABC transporters that confer resistance and counteract their antimicrobial activity. Two distinct ABC transporter families are known to be involved in this process. These are the Cpr- and Bce-type ABC transporter families, named after their involvement in cationic peptide resistance in Clostridium difficile, and bacitracin efflux in Bacillus subtilis, respectively. Both resistance systems differentiate to each other in terms of the proteins involved. Here, we summarize the current knowledge and describe the divergence as well as the common features present in both the systems to confer lantibiotic resistance.

Type: Article
Title: Insight into Two ABC Transporter Families Involved in Lantibiotic Resistance
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fmolb.2017.00091
Publisher version: http://doi.org/10.3389/fmolb.2017.00091
Language: English
Additional information: Copyright © 2018 Clemens, Zaschke-Kriesche, Khosa and Smits. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: lanthionine ring, lantibiotic, nisin, resistance, antimicrobial peptide, L. lactis
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/10053219
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