Clout, AE;
Buanz, ABM;
Gaisford, S;
Williams, G;
(2018)
Polymorphic phase transitions in carbamazepine and 10,11-dihydrocarbamazepine.
Chemistry - A European Journal
, 24
(51)
pp. 13573-13581.
10.1002/chem.201802368.
Preview |
Text
Clout_Polymorphic Phase Transitions in Carbamazepine and 10%2C11-Dihydrocarbamazepine.pdf - Published Version Download (1MB) | Preview |
Abstract
Temperature-induced phase transitions in carbamazepine (CBZ) and 1,10-dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry - X-ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localized melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 °C, by either a solid-solid pathway or a localised intermediate melt phase. CBZ form II converted to form I at 119 °C by a pathway that appears to have included some melting, and form III underwent a part melt-recrystallisation and a part sublimation-recrystallisation to form I.
| Type: | Article |
|---|---|
| Title: | Polymorphic phase transitions in carbamazepine and 10,11-dihydrocarbamazepine |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/chem.201802368 |
| Publisher version: | https://doi.org/10.1002/chem.201802368 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Phase transitions, hyphenated techniques, pharmaceutical materials, synchrotron X-ray diffraction, thermal analysis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10052958 |
Archive Staff Only
 |
View Item |
