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Assessment of dialysis adequacy: beyond urea kinetic measurements

Rees, L; (2018) Assessment of dialysis adequacy: beyond urea kinetic measurements. Pediatric Nephrology 10.1007/s00467-018-3914-6. (In press). Green open access

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Adequacy of dialysis is a term that has been used for many years based on measurement of small solute clearance using urea and creatinine. This has been shown in some but not all studies in adults to correlate with survival. However, small solute clearance is just one minor part of the effectiveness of dialysis and in fact 'optimum' dialysis, rather than 'adequate' dialysis is what most paediatric nephrologists would want for their patients. Additional ways to assess the success of dialysis in children would include dialysis access complications and longevity, preservation of residual kidney function, body composition, biochemical and haematological control, nutrition and growth, discomfort during the dialysis process and psychosocial adjustment including hospitalisation and school attendance. These criteria need to be balanced against a dialysis programme that has the least possible adverse effects on quality of life.

Type: Article
Title: Assessment of dialysis adequacy: beyond urea kinetic measurements
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00467-018-3914-6
Publisher version: https://doi.org/10.1007/s00467-018-3914-6
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons. org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Adequacy, Dialysis, Optimum dialysis
URI: http://discovery.ucl.ac.uk/id/eprint/10052250
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