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Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics

Balint, B; Wiethoff, S; Martino, D; Del Gamba, C; Latorre, A; Ganos, C; Houlden, H; (2018) Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics. Movement Disorders Clinical Practice , 5 (3) pp. 317-320. 10.1002/mdc3.12615. Green open access

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Abstract

Background: Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterised by brief attacks of chorea, dystonia, or mixed forms precipitated by sudden movement. Methods: Observational study with a cohort of 14 PKD patients and genetic testing for PRRT2 mutations. Results: In a series of 14 PKD patients seen in our clinic at the National Hospital of Neurology, Queen Square, from 2012-2017, we noted tics in 11 patients (79%), which stand in stark contrast to the estimated lifetime prevalence of tics estimated to reach 1%. Conclusions: The two reasons to point out this possible association are the clinical implications and the potential opportunity of a better understanding of shared pathophysiological mechanisms of neuronal hyperexcitability.

Type: Article
Title: Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mdc3.12615
Publisher version: https://doi.org/10.1002/mdc3.12615
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: PRRT2, paroxysmal kinesigenic dyskinesia (PKD), tics
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/10052127
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