UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases

Choi, ML; Gandhi, S; (2018) Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases. The FEBS Journal , 285 (19) pp. 3631-3644. 10.1111/febs.14587. Green open access

[img]
Preview
Text
Choi_et_al-2018-The_FEBS_Journal.pdf - ["content_typename_Published version" not defined]

Download (285kB) | Preview

Abstract

Misfolding and aggregation of the proteins amyloid-β (Aβ), tau and alpha-synuclein (α-syn) is the predominant pathology underlying the neurodegenerative disorders, Alzheimer's and Parkinson's disease. Whilst end stage insoluble products of aggregation have been well characterised in human and animal models of disease, accumulating evidence from biophysical, cellular and in vivo studies has shown that soluble intermediates of aggregation, or oligomers, may be the key species that mediate toxicity and underlie seeding and spreading in disease. Here we review the process of protein misfolding, and the intrinsic and extrinsic processes that cause the native states of the key aggregating proteins to undergo conformational change to form oligomers and ultimately fibrils. We discuss the structural features of the key toxic intermediate, and describe the putative mechanisms by which oligomers may cause cell toxicity. Finally we explore the potential therapeutic approaches raised by the oligomer hypothesis in neurodegenerative disease. This article is protected by copyright. All rights reserved.

Type: Article
Title: Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/febs.14587
Publisher version: http://dx.doi.org/10.1111/febs.14587
Language: English
Additional information: Copyright © 2018 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Alzheimer's disease, Parkinson's disease, alpha-synuclein, amyloid-β, oligomer, protein misfolding, tau
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/10051918
Downloads since deposit
66Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item