Schwenk, S;
Arnvig, KB;
(2018)
Regulatory RNA in Mycobacterium tuberculosis, back to basics.
Pathogens and Disease
, 76
(4)
, Article fty035. 10.1093/femspd/fty035.
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Abstract
Since the turn of the millenium, RNA-based control of gene expression has added an extra dimension to the central dogma of molecular biology. Still, the roles of Mycobacterium tuberculosis regulatory RNAs and the proteins that facilitate their functions remain elusive, although there can be no doubt that RNA biology plays a central role in the baterium's adaptation to its many host environments. In this review, we have presented examples from model organisms and from M. tuberculosis to showcase the abundance and versatility of regulatory RNA, in order to emphasise the importance of these 'fine-tuners' of gene expression.
| Type: | Article |
|---|---|
| Title: | Regulatory RNA in Mycobacterium tuberculosis, back to basics |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/femspd/fty035 |
| Publisher version: | https://doi.org/10.1093/femspd/fty035 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Mycobacterium tuberculosis, post-transcriptional regulation, regulatory RNA, small RNA, riboswitch, riboregulation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051467 |
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