Polonsky, M;
Rimer, J;
Kern-Perets, A;
Zaretsky, I;
Miller, S;
Bornstein, C;
David, E;
... Friedman, N; + view all
(2018)
Induction of CD4 T cell memory by local cellular collectivity.
Science
, 360
(6394)
, Article eaaj1853. 10.1126/science.aaj1853.
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Abstract
he balance between effector and central memory T cells shifts toward the latter as the number of T cells participating in immune responses increases. Polonsky et al. determined the mechanisms by which T cell quorum sensing affects memory differentiation by using live-cell imaging to track cell proliferation and differentiation. They found that the rate of memory CD4+ T cell differentiation is determined by cell number. This rate substantially increases above a threshold number of locally interacting cells. Mathematical modeling suggests that the number of initially seeded cells and the number of cell divisions are not critical. Instead, the instantaneous number of interacting cells continuously modulates the differentiation rate. This is partly fueled by increased sensitivity to the cytokines interleukin-2 (IL-2) and IL-6, independent of any effects on cell proliferation.
| Type: | Article |
|---|---|
| Title: | Induction of CD4 T cell memory by local cellular collectivity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/science.aaj1853 |
| Publisher version: | http://dx.doi.org/10.1126/science.aaj1853 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, Lymphocyte Division, CD8(+) Effector, Differentiation, Generation, Infection, Expansion, Activation, Expression, Immunity, Specification |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10051434 |
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