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Investigation and management of a raised serum ferritin

Cullis, JO; Fitzsimons, EJ; Griffiths, WJH; Tsochatzis, E; Thomas, DW; (2018) Investigation and management of a raised serum ferritin. British Journal of Haematology , 181 (3) pp. 331-340. 10.1111/bjh.15166. Green open access

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Abstract

Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal disease, malignancy, and the recently described metabolic syndrome. A key test in the further investigation of an unexpected raised serum ferritin is the serum transferrin saturation. This guideline reviews the investigation and management of a raised serum ferritin level. The investigation and management of genetic haemochromatosis is not dealt with however and is the subject of a separate guideline.

Type: Article
Title: Investigation and management of a raised serum ferritin
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bjh.15166
Publisher version: https://doi.org/10.1111/bjh.15166
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Hematology, Hyperferritinaemia, Ferritin, Iron Metabolism, Liver Iron Concentration, Normal Transferrin Saturation, Porphyria-Cutanea-Tarda, Type-1 Gaucher-Disease, Deficiency Anemia, Dysmetabolic Hyperferritinemia, Extreme Hyperferritinemia, Overload, Hemochromatosis, Receptor
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/10050697
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