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Vascular regulation of glioma stem-like cells: a balancing act

Brooks, LJ; Parrinello, S; (2017) Vascular regulation of glioma stem-like cells: a balancing act. Current Opinion in Neurobiology , 47 pp. 8-15. 10.1016/j.conb.2017.06.008. Green open access

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Abstract

Glioblastoma (GBM) are aggressive and therapy-resistant brain tumours driven by glioma stem-like cells (GSCs). GSC behaviour is controlled by the microenvironment, or niche, in which the cells reside. It is well-established that the vasculature is a key component of the GSC niche, which drives maintenance in the tumour bulk and invasion at the margin. Emerging evidence now indicates that the specific properties of the vasculature within these two regions impose different functional states on resident GSCs, generating distinct subpopulations. Here, we review these recent findings, focusing on the mechanisms that underlie GSC/vascular communication. We further discuss how plasticity enables GSCs to respond to vascular changes by interconverting bidirectionally between states, and address the therapeutic implications of this dynamic response.

Type: Article
Title: Vascular regulation of glioma stem-like cells: a balancing act
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.conb.2017.06.008
Publisher version: https://doi.org/10.1016/j.conb.2017.06.008
Language: English
Additional information: Copyright © 2017 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
URI: http://discovery.ucl.ac.uk/id/eprint/10050138
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