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Modelling multi-scale cell-tissue interaction of tissue-engineered muscle constructs

Mudera, C; Torii, R; Hodgson, D; Velliou, R; (2018) Modelling multi-scale cell-tissue interaction of tissue-engineered muscle constructs. Journal of Tissue Engineering (In press). Green open access

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Abstract

Expectation on engineered tissue substitute continues to grow and for an effective development of a functional tissue and to control its quality, cellular mehcanoresponse plays a key role. Although the mechanoresponse – in terms of cell-tissue interaction across scales – has been understood better in recent years, there are still technical limitations to quantitatively monitor the processes involved in the development of both native and engineered tissues. Computational (in silico) studies have been utilised to complement the experimental limitations and successfully applied to prediction of tissue growth. We here review recent activities in the area of combined experimental and computational analyses of tissue growth, especially in tissue-engineering context, and highlight the advantages of such an approach for the future of the tissue engineering, using our own case study of predicting musculoskeletal tissue-engineering construct development.

Type: Article
Title: Modelling multi-scale cell-tissue interaction of tissue-engineered muscle constructs
Open access status: An open access version is available from UCL Discovery
Publisher version: http://journals.sagepub.com/home/tej
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
URI: http://discovery.ucl.ac.uk/id/eprint/10050133
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