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Hippocampal subfield volumetry: differential pattern of atrophy in different forms of genetic frontotemporal dementia

Bocchetta, M; Iglesias, JE; Scelsi, M; Cash, D; Cardoso, MJ; Modat, M; Altmann, A; ... Rohrer, JD; + view all (2018) Hippocampal subfield volumetry: differential pattern of atrophy in different forms of genetic frontotemporal dementia. Journal of Alzheimer's Disease 10.3233/JAD-180195. (In press). Green open access

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Abstract

BACKGROUND: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder, with a strong genetic component. Previous research has shown that medial temporal lobe atrophy is a common feature of FTD. However, no study has so far investigated the differential vulnerability of the hippocampal subfields in FTD. OBJECTIVES: We aimed to investigate hippocampal subfield volumes in genetic FTD. METHODS: We in6/2/2018vestigated hippocampal subfield volumes in a cohort of 75 patients with genetic FTD (age: mean (standard deviation) 59.3 (7.7) years; disease duration: 5.1(3.4) years; 29 with MAPT, 28 with C9orf72, and 18 with GRN mutations) compared with 97 age-matched controls (age: 62.1 (11.1) years). We performed a segmentation of their volumetric T1-weighted MRI scans to extract hippocampal subfields volumes. Left and right volumes were summed and corrected for total intracranial volumes. RESULTS: All three groups had smaller hippocampi than controls. The MAPT group had the most atrophic hippocampi, with the subfields showing the largest difference from controls being CA1-4 (24–27%, p < 0.0005). For C9orf72, the CA4, CA1, and dentate gyrus regions (8–11%, p < 0.0005), and for GRN the presubiculum and subiculum (10–14%, p < 0.0005) showed the largest differences from controls. CONCLUSIONS: The hippocampus was affected in all mutation types but a different pattern of subfield involvement was found in the three genetic groups, consistent with differential cortical-subcortical network vulnerability.

Type: Article
Title: Hippocampal subfield volumetry: differential pattern of atrophy in different forms of genetic frontotemporal dementia
Open access status: An open access version is available from UCL Discovery
DOI: 10.3233/JAD-180195
Publisher version: http://dx.doi.org/10.3233/JAD-180195
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: genetic frontotemporal dementia, MRI, hippocampal subfields, volumetry
URI: http://discovery.ucl.ac.uk/id/eprint/10050123
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