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Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease

Barnes, J; Bartlett, J; Wolk, D; van der Flier, W; Frost, C; (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. Journal of Alzheimer's Disease 10.3233/JAD-170841. (In press). Green open access

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Abstract

Health-care professionals, patients, and families seek as much information as possible about prognosis for patients with Alzheimer’s disease (AD); however, we do not yet have a robust understanding of how demographic factors predict prognosis. We evaluated associations between age at presentation, age of onset, and symptom length with cognitive decline as measured using the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating sum-of-boxes (CDR-SOB) in a large dataset of AD patients. Age at presentation was associated with post-presentation decline in MMSE (p < 0.001), with younger patients showing faster decline. There was little evidence of an association with change in CDR-SOB. Symptom length, rather than age, was the strongest predictor of MMSE and CDR-SOB at presentation, with increasing symptom length associated with worse outcomes. The evidence that younger AD patients have a more aggressive disease course implies that early diagnosis is essential.

Type: Article
Title: Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.3233/JAD-170841
Publisher version: http://dx.doi.org/10.3233/JAD-170841
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Age Factors; Alzheimer Disease; cognition; age of onset; cognitive decline
URI: http://discovery.ucl.ac.uk/id/eprint/10050117
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