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The LRRK2 signalling system

Price, A; Manzoni, C; Cookson, MR; Lewis, PA; (2018) The LRRK2 signalling system. Cell and Tissue Research 10.1007/s00441-017-2759-9. Green open access

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The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson's research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the cell. Because of the complexities of the signal transduction pathways in which LRRK2 is involved, it has been challenging to generate a clear idea as to how mutations and disease associated variants in this gene are altered in disease. Understanding the events in which LRRK2 is involved at a systems level is therefore critical to fully understand the biology and pathobiology of this protein and is the subject of this review.

Type: Article
Title: The LRRK2 signalling system
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00441-017-2759-9
Publisher version: http://doi.org/10.1007/s00441-017-2759-9
Language: English
Additional information: Copyright © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Kinase, LRRK2, Parkinson’s disease, ROCO protein, Signal transduction
URI: http://discovery.ucl.ac.uk/id/eprint/10049912
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