UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

NDUFA4 (Renamed COXFA4) Is a Cytochrome-c Oxidase Subunit

Pitceathly, RDS; Taanman, J-W; (2018) NDUFA4 (Renamed COXFA4) Is a Cytochrome-c Oxidase Subunit. [Letter]. Trends in Endocrinology & Metabolism , 29 (7) pp. 452-454. 10.1016/j.tem.2018.03.009. Green open access

[img]
Preview
Text
Pitceathly Taanman TIEM 2018.pdf - ["content_typename_Accepted version" not defined]

Download (415kB) | Preview

Abstract

Groundbreaking work by Kadenbach and colleagues in the 1980s revealed the presence of 13 subunits in the mammalian mitochondrial cytochrome-c oxidase (COX; Complex IV). This observation stood the test of time until 2012 when it was demonstrated that NDUFA4, a polypeptide previously attributed to mitochondrial Complex I, was a 14th subunit of COX. In his recent opinion article, Kadenbach argued that NDUFA4 is not a subunit of COX. However, based on the findings that NDUFA4 deficiency results in a severe loss of COX activity and that NDUFA4 represents a stoichiometric component of the individual COX complex, we reason that NDUFA4 is a bona fide COX subunit and propose renaming it as COX subunit FA4 (COXFA4).

Type: Article
Title: NDUFA4 (Renamed COXFA4) Is a Cytochrome-c Oxidase Subunit
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tem.2018.03.009
Publisher version: http://dx.doi.org/10.1016/j.tem.2018.03.009
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: COXFA4, NDUFA4, cytochrome-c oxidase, detergent, electron transport chain, mitochondria
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/10049693
Downloads since deposit
43Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item