Fina, F;
Goyanes, A;
Madla, CM;
Awad, A;
Trenfield, SJ;
Kuek, JM;
Patel, P;
... Basit, AW; + view all
(2018)
3D printing of drug-loaded gyroid lattices using selective laser sintering.
International Journal of Pharmaceutics
, 547
(1-2)
pp. 44-52.
10.1016/j.ijpharm.2018.05.044.
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Abstract
Three-dimensional printing (3DP) is gaining momentum in the field of pharmaceuticals, offering innovative opportunities for medicine manufacture. Selective laser sintering (SLS) is a novel, high resolution and single-step printing technology that we have recently introduced to the pharmaceutical sciences. The aim of this work was to use SLS 3DP to fabricate printlets (3D printed tablets) with cylindrical, gyroid lattice and bi-layer structures having customisable release characteristics. Paracetamol-loaded constructs from four different pharmaceutical grade polymers including polyethylene oxide, Eudragit (L100-55 and RL) and ethyl cellulose, were created using SLS 3DP. The novel gyroid lattice structure was able to modulate the drug release from all four polymers. This work is the first to demonstrate the feasibility of using SLS to achieve customised drug release properties of several polymers, in a swift, cost-effective manner, avoiding the need to alter the formulation composition. By creating these constructs, it is therefore possible to modify drug release, which in practice, could enable the tailoring of drug performance to the patient simply by changing the 3D design.
Type: | Article |
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Title: | 3D printing of drug-loaded gyroid lattices using selective laser sintering |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.ijpharm.2018.05.044 |
Publisher version: | https://doi.org/10.1016/j.ijpharm.2018.05.044 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Rapid prototyping, Additive manufacturing, Personalized medicines, Acrylic polymers, Fused deposition modeling (FDM), Stereolithography (SLA) |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
URI: | https://discovery.ucl.ac.uk/id/eprint/10049636 |
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