McInnes, SJP;
Macdonald, TJ;
Parkin, IP;
Nann, T;
Voelcker, NH;
(2018)
Electrospun composites of polycaprolactone and porous silicon nanoparticles for the tunable delivery of small therapeutic molecules.
Nanomaterials
, 8
(4)
, Article 205. 10.3390/nano8040205.
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Abstract
This report describes the use of an electrospun composite of poly(ε-caprolactone) (PCL) fibers and porous silicon (pSi) nanoparticles (NPs) as an effective system for the tunable delivery of camptothecin (CPT), a small therapeutic molecule. Both materials are biodegradable, abundant, low-cost, and most importantly, have no known cytoto xic effects. The composites were treated with and without sodium hydroxide (NaOH) to investigate the wettability of the porous network for drug release and cell viability measurements. CPT release and subsequent cell viability was also investigated. We observed that the cell death rate was not only affected by the addition of our CPT carrier, pSi, but also by increasing the rate of dissolution via treatment with NaOH. This is the first example of loading pSi NPs as a therapeutics nanocarrier into electronspun PCL fibers and this system opens up new possibilities for the delivery of molecular therapeutics.
Type: | Article |
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Title: | Electrospun composites of polycaprolactone and porous silicon nanoparticles for the tunable delivery of small therapeutic molecules |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.3390/nano8040205 |
Publisher version: | https://doi.org/10.3390/nano8040205 |
Language: | English |
Additional information: | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Porous silicon; drug delivery; electrospinning; poly(ε-caprolactone) |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/10048324 |
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