UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Electrospun composites of polycaprolactone and porous silicon nanoparticles for the tunable delivery of small therapeutic molecules

McInnes, SJP; Macdonald, TJ; Parkin, IP; Nann, T; Voelcker, NH; (2018) Electrospun composites of polycaprolactone and porous silicon nanoparticles for the tunable delivery of small therapeutic molecules. Nanomaterials , 8 (4) , Article 205. 10.3390/nano8040205. Green open access

[img]
Preview
Text
nanomaterials-08-00205.pdf - ["content_typename_Published version" not defined]

Download (24MB) | Preview

Abstract

This report describes the use of an electrospun composite of poly(ε-caprolactone) (PCL) fibers and porous silicon (pSi) nanoparticles (NPs) as an effective system for the tunable delivery of camptothecin (CPT), a small therapeutic molecule. Both materials are biodegradable, abundant, low-cost, and most importantly, have no known cytoto xic effects. The composites were treated with and without sodium hydroxide (NaOH) to investigate the wettability of the porous network for drug release and cell viability measurements. CPT release and subsequent cell viability was also investigated. We observed that the cell death rate was not only affected by the addition of our CPT carrier, pSi, but also by increasing the rate of dissolution via treatment with NaOH. This is the first example of loading pSi NPs as a therapeutics nanocarrier into electronspun PCL fibers and this system opens up new possibilities for the delivery of molecular therapeutics.

Type: Article
Title: Electrospun composites of polycaprolactone and porous silicon nanoparticles for the tunable delivery of small therapeutic molecules
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/nano8040205
Publisher version: https://doi.org/10.3390/nano8040205
Language: English
Additional information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Porous silicon; drug delivery; electrospinning; poly(ε-caprolactone)
URI: http://discovery.ucl.ac.uk/id/eprint/10048324
Downloads since deposit
7Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item