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Tensile Forces and Mechanotransduction at Cell-Cell Junctions

Charras, G; Yap, AS; (2018) Tensile Forces and Mechanotransduction at Cell-Cell Junctions. Current Biology , 28 (8) R445-R457. 10.1016/j.cub.2018.02.003. Green open access

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Abstract

Cell-cell junctions are specializations of the plasma membrane responsible for physically integrating cells into tissues. We are now beginning to appreciate the diverse impacts that mechanical forces exert upon the integrity and function of these junctions. Currently, this is best understood for cadherin-based adherens junctions in epithelia and endothelia, where cell-cell adhesion couples the contractile cytoskeletons of cells together to generate tissue-scale tension. Junctional tension participates in morphogenesis and tissue homeostasis. Changes in tension can also be detected by mechanotransduction pathways that allow cells to communicate with each other. In this review, we discuss progress in characterising the forces present at junctions in physiological conditions; the cellular mechanisms that generate intrinsic tension and detect changes in tension; and, finally, we consider how tissue integrity is maintained in the face of junctional stresses.

Type: Article
Title: Tensile Forces and Mechanotransduction at Cell-Cell Junctions
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cub.2018.02.003
Publisher version: https://doi.org/10.1016/j.cub.2018.02.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/10048163
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