Harper, JC;
Aittomaki, K;
Borry, P;
Cornel, MC;
de Wert, G;
Dondorp, W;
Geraedts, J;
... European Society of Human Genetics, .; + view all
(2018)
Recent developments in genetics and medically assisted reproduction: from research to clinical applications.
European Journal of Human Genetics
, 26
pp. 12-33.
10.1038/s41431-017-0016-z.
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Abstract
Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.
| Type: | Article |
|---|---|
| Title: | Recent developments in genetics and medically assisted reproduction: from research to clinical applications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41431-017-0016-z |
| Publisher version: | http://dx.doi.org/10.1038/s41431-017-0016-z |
| Language: | English |
| Additional information: | Open Access: This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by-nc-sa/4.0/. |
| Keywords: | Assisted reproductive technology, Epigenetics, Expanded carrier screening, Gamete donor anonymity, Germline genome editing, Female infertility, Male infertility, Mitochondrial replacement therapy, Non-invasive prenatal testing, Preimplantation genetic testing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047672 |
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