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Polymer-Magnetic Composite Fibers for Remote-Controlled Drug Release

Perera, AS; Zhang, S; Homer-Vanniasinkam, S; Coppens, M-O; Edirisinghe, M; (2018) Polymer-Magnetic Composite Fibers for Remote-Controlled Drug Release. Applied Materials and Interfaces , 10 (18) pp. 15524-15531. 10.1021/acsami.8b04774. Green open access

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Abstract

An efficient method is reported, for fabrication of composite microfibers that can be magnetically actuated and are biocompatible, targeting controlled drug release. Aqueous solutions of polyvinyl alcohol (PVA), incorporated with citric acid coated Fe3O4 magnetic nanoparticles (MNPs), are subject to infusion gyration, to generate 100-300 nm diameter composite fibers, with controllable MNP loading. The fibers are stable in polar solvents, such as ethanol, and do not show any leaching of MNPs for over 4 weeks. Using acetaminophen as an example, we demonstrate that, this material is effective in immobilization and triggered release of drugs, achieved by a moving external magnetic field. The remote actuation ability, coupled with biocompatibility and lightweight property, renders enormous potential for these fibers to be used as a smart drug-release agent.

Type: Article
Title: Polymer-Magnetic Composite Fibers for Remote-Controlled Drug Release
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsami.8b04774
Publisher version: http://doi.org/10.1021/acsami.8b04774
Language: English
Additional information: This is an open access article published under a Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Keywords: Nanofibers, nanomaterials, polymer-magnetic composites, magnetic actuation, controlled drug release, infusion gyration
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/10047431
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