Carreira, PL;
Isenberg, DA;
(2019)
Recent developments in biologic therapies for the treatment of patients with systemic lupus erythematosus.
Rheumatology
, 58
(3)
pp. 382-287.
10.1093/rheumatology/key064.
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Abstract
SLE has a complex pathogenesis, and multiple therapeutic targets have been discovered in recent years. In spite of belimumab being approved by the US Food and Drug Administration and the widespread use of rituximab, there have been many failed attempts to treat SLE successfully using biologic agents. In this review, we consider newer biologic approaches that might offer the hope of improving the outcome of SLE patients. These include the fully humanized anti-CD20 mAbs, PEGylated anti-CD40L, IFNα inhibitors, rigerimod and immune complexes blockade.
| Type: | Article |
|---|---|
| Title: | Recent developments in biologic therapies for the treatment of patients with systemic lupus erythematosus |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/rheumatology/key064 |
| Publisher version: | https://doi.org/10.1093/rheumatology/key064 |
| Language: | English |
| Additional information: | © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Lupus, biologic, anti-CD20, anti-CD40L, dapirolizumab, ofatumumab, obinutuzumab, rigerimod, interferon, FCγR |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047220 |
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