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Microfluidic Devices for Examining the Physical Limits of Migration in Confined Environments

Malboubi, M; Jayo, A; Parsons, M; Charras, G; (2018) Microfluidic Devices for Examining the Physical Limits of Migration in Confined Environments. Methods in Molecular Biology , 1749 pp. 375-386. 10.1007/978-1-4939-7701-7_27. Green open access

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Abstract

Cell migration plays a key role in many physiological and pathological conditions during which cells migrate primarily in the 3D environments formed by tissues. Microfluidics enables the design of simple devices that can mimic in a highly controlled manner the geometry and dimensions of the interstices encountered by cells in the body. Here we describe the design, fabrication, and implementation of an array of channels with a range of cross sections to investigate migration of cells and cell clusters through confined spaces. By combining this assay with a motorized microscope stage, image data can be acquired with high throughput to determine the physical limits of migration in confined environments and their biological origin.

Type: Article
Title: Microfluidic Devices for Examining the Physical Limits of Migration in Confined Environments
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4939-7701-7_27
Publisher version: http://dx.doi.org/10.1007/978-1-4939-7701-7_27
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Breast cancer cells, Cell deformation, Microfluidics, Multilayer photolithography
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/10046894
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