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No way out: when RNA elements promote nuclear retention

Agostini, F; Ule, J; Zagalak, JA; (2018) No way out: when RNA elements promote nuclear retention. EMBO Journal , 37 (6) , Article e99123. 10.15252/embj.201899123. Green open access

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Abstract

The proper localization of RNA transcripts is a highly controlled and fine‐tuned process. Indeed, regulation of RNA trafficking is mediated by both cis‐acting elements and trans‐acting factors, and defects in either mechanism have been associated with disease. Identifying the RNA sequence motifs that determine cellular localization for a given transcript therefore represents an important and challenging task. A new study from Shukla et al in The EMBO Journal—along with related work from Lubelsky and Ulitsky published elsewhere—describes a new screen that uses hybrid RNAs with barcoded oligonucleotides to identify cis‐acting elements that increase the propensity of RNAs to be retained in the nuclear compartment.

Type: Article
Title: No way out: when RNA elements promote nuclear retention
Open access status: An open access version is available from UCL Discovery
DOI: 10.15252/embj.201899123
Publisher version: http://dx.doi.org/10.15252/embj.201899123
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, Localization, Expression
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/10046646
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