UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Distal Esophageal Adenocarcinoma and Gastric Adenocarcinoma: Time for a Shared Research Agenda

Jansen, M; Wright, NA; (2016) Distal Esophageal Adenocarcinoma and Gastric Adenocarcinoma: Time for a Shared Research Agenda. Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract , 908 pp. 1-8. 10.1007/978-3-319-41388-4_1.

[img] Text
Jansen_complete.pdf - ["content_typename_Accepted version" not defined]
Access restricted to UCL open access staff

Download (4MB)

Abstract

The key insight that sparked Darwin’s theory of descent with modification was that he compared and contrasted differences between living and extinct species across time and space. He likely arrived on this theory in large part through his culinary experiences, set against the background of the rugged Patagonian landscape of Southern Argentina. We feel that further integration of research into gastric and esophageal adenocarcinoma may benefit both fields and similarly lead to a coherent understanding of cancer progression in the upper gastrointestinal tract across time and space. Although the environmental trigger differs between carcinogenesis of the stomach and distal esophagus, there remain many important lessons to be learned from comparing precursor stages, such as intestinal metaplasia, across anatomic borders. This analysis will absolutely require detailed sampling within and between these related species, but most importantly we need higher resolution clinical phenotyping to relate genomic differences to drivers of morphologic evolution. In the end, this may provide us with a new phylogeny showing key differences between esophageal and gastric adenocarcinoma.

Type: Article
Title: Distal Esophageal Adenocarcinoma and Gastric Adenocarcinoma: Time for a Shared Research Agenda
DOI: 10.1007/978-3-319-41388-4_1
Publisher version: https://doi.org/10.1007/978-3-319-41388-4_1
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Gastroenterology & Hepatology, BARRETTS-ESOPHAGUS, CANCER
URI: http://discovery.ucl.ac.uk/id/eprint/10046576
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item