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Processing methods for photoacoustic Doppler flowmetry with a clinical ultrasound scanner

Bücking, TM; van den Berg, PJ; Balabani, S; Steenbergen, W; Beard, PC; Brunker, J; (2018) Processing methods for photoacoustic Doppler flowmetry with a clinical ultrasound scanner. Journal of Biomedical Optics , 23 (2) , Article 026009. 10.1117/1.JBO.23.2.026009. Green open access

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Abstract

Photoacoustic flowmetry (PAF) based on time-domain cross correlation of photoacoustic signals is a promising technique for deep tissue measurement of blood flow velocity. Signal processing has previously been developed for single element transducers. Here, the processing methods for acoustic resolution PAF using a clinical ultrasound transducer array are developed and validated using a 64-element transducer array with a -6 dB detection band of 11 to 17 MHz. Measurements were performed on a flow phantom consisting of a tube (580  μm inner diameter) perfused with human blood flowing at physiological speeds ranging from 3 to 25  mm  /  s. The processing pipeline comprised: image reconstruction, filtering, displacement detection, and masking. High-pass filtering and background subtraction were found to be key preprocessing steps to enable accurate flow velocity estimates, which were calculated using a cross-correlation based method. In addition, the regions of interest in the calculated velocity maps were defined using a masking approach based on the amplitude of the cross-correlation functions. These developments enabled blood flow measurements using a transducer array, bringing PAF one step closer to clinical applicability.

Type: Article
Title: Processing methods for photoacoustic Doppler flowmetry with a clinical ultrasound scanner
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/1.JBO.23.2.026009
Publisher version: https://doi.org/10.1117/1.JBO.23.2.026009
Language: English
Additional information: Copyright © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Keywords: flowmetry; blood flow; photoacoustic Doppler effect; cross correlation; transducer array; image processing; masking
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/10046547
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