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Cancer Evolution Constrained by the Immune Microenvironment

McGranahan, N; Swanton, C; (2017) Cancer Evolution Constrained by the Immune Microenvironment. CELL , 170 (5) pp. 825-827. 10.1016/j.cell.2017.08.012. Green open access

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Abstract

Tumor development is a Darwinian evolutionary process, involving the interplay between cancer subclones and the local immune microenvironment. These complex interactions are highlighted in this issue of Cell by the results from Jiménez-Sánchez et al. of a deep analysis of one patient with advanced serous carcinoma of the ovary.

Type: Article
Title: Cancer Evolution Constrained by the Immune Microenvironment
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2017.08.012
Publisher version: https://doi.org/10.1016/j.cell.2017.08.012
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, CHECKPOINT BLOCKADE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/10046469
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