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A Comparison of Electric-Field-Driven and Pressure-Driven Fiber Generation Methods for Drug Delivery

Ahmed, J; Matharu, RK; Shams, T; Illangakoon, UE; Edirisinghe, M; (2018) A Comparison of Electric-Field-Driven and Pressure-Driven Fiber Generation Methods for Drug Delivery. Macromolecular Materials and Engineering , 303 (5) , Article 1700577. 10.1002/mame.201700577. Green open access

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Abstract

Polymeric fibers are prepared by using electric field driven fiber production technology-electrospinning and pressure driven fiber production technology-pressurized gyration. Fibers of four different polymers: polyvinylidene fluoride (PVDF), poly(methyl methacrylate (PMMA), poly(N-isopropylacrylamide), and polyvinylpyridine (PVP), are spun by both techniques and differences are analyzed for their suitability as drug carriers. The diameters of electrospun fibers are larger in some cases (PVDF and PMMA), producing fibers with lower surface area. Pressurized gyration allows for a higher rate of fiber production. Additionally, drug-loaded PVP fibers are prepared by using two poorly water-soluble drugs (Amphotericin B and Itraconazole). In vitro dissolution studies show differences in release rate between the two types of fibers. Drug-loaded gyrospun fibers release the drugs faster within 15 min compared to the drug-loaded electrospun fibers. The findings suggest pressurized gyration is a promising and scalable approach to rapid fiber production for drug delivery when compared to electrospinning.

Type: Article
Title: A Comparison of Electric-Field-Driven and Pressure-Driven Fiber Generation Methods for Drug Delivery
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mame.201700577
Publisher version: https://doi.org/10.1002/mame.201700577
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: pressure; gyration; electrospinning; fibers; drug delivery
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/10046459
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