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3D Bioprinting of stimuli-responsive polymers synthesised from DE-ATRP into soft tissue replicas

Aied, A; Song, W; Wang, W; Baki, A; Sigen, A; (2018) 3D Bioprinting of stimuli-responsive polymers synthesised from DE-ATRP into soft tissue replicas. Bioprinting , 9 pp. 37-43. 10.1016/j.bprint.2018.02.002. Green open access

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Abstract

Synthetic polymers possess more reproducible physical and chemical properties than their naturally occurring counterparts. They have also emerged as an important alternative for fabricating tissue substitutes because they can be molecularly tailored to have vast array of molecular weights, block structures, active functional groups, and mechanical properties. To this date however, there has been very few successful and fully functional synthetic tissue and organ substitutes and with the rapidly spreading 3D printing technology beginning to reshape the tissue engineering and regenerative field, the need for an effective, safe, and bio printable biomaterial is becoming more and more urgent. Here, we have developed a synthetic polymer from controlled living radical polymerization that can be printed into well-defined structures. The polymer showed low cytotoxicity before and after printing. Additionally, the incorporation of gelatine-methacrylate coated PLGA microparticles within the hydrogel provided cell adhesion surfaces for cell proliferation. The results point to possible application of the microparticle seeded, synthetic hydrogel as a direct printable tissue or organ substitute.

Type: Article
Title: 3D Bioprinting of stimuli-responsive polymers synthesised from DE-ATRP into soft tissue replicas
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bprint.2018.02.002
Publisher version: https://doi.org/10.1016/j.bprint.2018.02.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Bioprinting, Tissue Engineering, Hydrogels, Synthetic polymer
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/10046236
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