Frankel, JP;
Kempster, PA;
Stibe, CM;
Eatough, VM;
Nathanson, M;
Lees, AJ;
Stern, GM;
(1989)
A double-blind, controlled study of high-dose L-deprenyl in the treatment of Parkinson's disease.
Clin Neuropharmacol
, 12
(5)
pp. 448-451.
Abstract
The conventional dose of deprenyl used in Parkinson's disease is 10 mg/day, having been established by in vitro platelet studies and clinical evaluation. Twelve patients with Parkinson's disease on treatment with L-dopa who showed evidence of wearing-off effects or motor oscillation were studied in a double-blind, placebo-controlled, crossover trial to compare conventional doses of deprenyl with higher doses (up to 40 mg/day) and placebo. We did not find higher doses of deprenyl to be superior to conventional doses and in 17% of cases treatment had to be withdrawn because of side effects.
| Type: | Article |
|---|---|
| Title: | A double-blind, controlled study of high-dose L-deprenyl in the treatment of Parkinson's disease. |
| Location: | United States |
| Keywords: | Adjuvants, Pharmaceutic, Aged, Clinical Trials as Topic, Dose-Response Relationship, Drug, Double-Blind Method, Humans, Levodopa, Middle Aged, Parkinson Disease, Phenethylamines, Selegiline |
| UCL classification: | UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | http://discovery.ucl.ac.uk/id/eprint/1004615 |
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