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A double-blind, controlled study of high-dose L-deprenyl in the treatment of Parkinson's disease.

Frankel, JP; Kempster, PA; Stibe, CM; Eatough, VM; Nathanson, M; Lees, AJ; Stern, GM; (1989) A double-blind, controlled study of high-dose L-deprenyl in the treatment of Parkinson's disease. Clin Neuropharmacol , 12 (5) pp. 448-451.

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Abstract

The conventional dose of deprenyl used in Parkinson's disease is 10 mg/day, having been established by in vitro platelet studies and clinical evaluation. Twelve patients with Parkinson's disease on treatment with L-dopa who showed evidence of wearing-off effects or motor oscillation were studied in a double-blind, placebo-controlled, crossover trial to compare conventional doses of deprenyl with higher doses (up to 40 mg/day) and placebo. We did not find higher doses of deprenyl to be superior to conventional doses and in 17% of cases treatment had to be withdrawn because of side effects.

Type: Article
Title: A double-blind, controlled study of high-dose L-deprenyl in the treatment of Parkinson's disease.
Location: United States
Keywords: Adjuvants, Pharmaceutic, Aged, Clinical Trials as Topic, Dose-Response Relationship, Drug, Double-Blind Method, Humans, Levodopa, Middle Aged, Parkinson Disease, Phenethylamines, Selegiline
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1004615
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