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Verbal learning and hippocampal dysfunction in schizophrenia: A meta analysis

Antoniades, M; Schoeler, T; Radua, J; Valli, I; Allen, P; Kempton, MJ; McGuire, P; (2017) Verbal learning and hippocampal dysfunction in schizophrenia: A meta analysis. Neuroscience & Biobehavioral Reviews , 86 pp. 166-175. 10.1016/j.neubiorev.2017.12.001. Green open access

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Abstract

This meta-analysis summarizes research examining whether deficits in verbal learning are related to bilateral hippocampal volume reductions in patients with or at risk for schizophrenia and in healthy controls. 17 studies with 755 patients with schizophrenia (SCZ), 232 Genetic High Risk (GHR) subjects and 914 healthy controls (HC) were included. Pooled correlation coefficients were calculated between hemisphere (left, right or total) and type of recall (immediate or delayed) for each diagnostic group individually (SCZ, GHR and HC). In SCZ, left and right hippocampal volume positively correlated with immediate (r = 0.256, 0.230) and delayed (r = 0.132, 0.231) verbal recall. There was also a correlation between total hippocampal volume and delayed recall (r = 0.233). None of these correlations were significant in healthy controls. There was however, a positive correlation between left hippocampal volume and immediate recall in the GHR group (r = 0.356). The results suggest that hippocampal volume affects immediate and delayed verbal learning capacity in schizophrenia and provides further evidence of hippocampal dysfunction in the pathophysiology of schizophrenia.

Type: Article
Title: Verbal learning and hippocampal dysfunction in schizophrenia: A meta analysis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neubiorev.2017.12.001
Publisher version: https://doi.org/10.1016/j.neubiorev.2017.12.001
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Behavioral Sciences, Neurosciences, Neurosciences & Neurology, Cognition, Volume, MRI, Memory, Schizophrenia, Medial temporal lobe, ULTRA-HIGH-RISK, ACETYLCHOLINE-RECEPTOR AGONIST, 9-YEAR FOLLOW-UP, 1ST-EPISODE SCHIZOPHRENIA, MAGNETIC-RESONANCE, EPISODIC MEMORY, COGNITIVE DEFICITS, BIPOLAR DISORDER, AUTOBIOGRAPHICAL MEMORY, FUNCTIONAL CONNECTIVITY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/10045938
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