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Effect of donepezil on transcranial magnetic stimulation parameters in Alzheimer's disease

Hwang, YT; Rocchi, L; Hammond, P; Hardy, CJ; Warren, JD; Ridha, BH; Rothwell, J; (2018) Effect of donepezil on transcranial magnetic stimulation parameters in Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions , 4 pp. 103-107. 10.1016/j.trci.2018.02.001. Green open access

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Abstract

INTRODUCTION: There is a need for a reliable, noninvasive biomarker for Alzheimer's disease (AD). We assessed whether short-latency afferent inhibition (SAI), a transcranial magnetic stimulation paradigm that assesses cholinergic circuits of the brain, could become such a biomarker. METHODS: Nineteen patients with AD underwent four SAI testing sessions. The timing of their usual donepezil dose was altered to create different cholinergic states for each session. This was compared to the SAI results from 20 healthy subjects. RESULTS: SAI was not able to distinguish the different cholinergic states assessed in our study. There appeared to be a diurnal variation in cholinergic function in the control group, which was not present in the AD cohort. DISCUSSION: SAI does not appear to have a role in diagnosis and assessment of AD patients. The loss of diurnal variation, however, warrants further investigation as it may provide further biochemical insights about AD.

Type: Article
Title: Effect of donepezil on transcranial magnetic stimulation parameters in Alzheimer's disease
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.trci.2018.02.001
Publisher version: http://doi.org/10.1016/j.trci.2018.02.001
Language: English
Additional information: © 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Acetylcholinesterase inhibitor, Alzheimer's disease, Donepezil, Response to treatment, Short-latency afferent inhibition, Transcranial magnetic stimulation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/10045769
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