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Association between circulating levels of heat-shock protein 27 and aggressive periodontitis

Boniface, DR; Kaiser, F; Donos, N; Henderson, B; Alagarswarmy, R; Pelekos, G; Nibali, L; (2018) Association between circulating levels of heat-shock protein 27 and aggressive periodontitis. Cell Stress and Chaperones , 23 (5) pp. 847-856. 10.1007/s12192-018-0891-4. Green open access

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Abstract

Objectives: Heat-shock protein (Hsp) 27 is a major intracellular molecular chaperone and controller of intracellular responses to inflammatory signals. In the extracellular space, recombinant Hsp27 has been described to exert anti-inflammatory activities. The aim of this study was to assess the association between circulating levels of Hsp27 and different types of periodontitis. Materials and Methods: Pro- and anti-inflammatory cytokines as well as the stress proteins Hsp27 and Hsp60 with proposed anti- and pro-inflammatory properties, respectively, were measured by two-site ELISA in the serum of patients with Aggressive Periodontitis (AgP, n=30), Chronic Periodontitis (CP, n=29), and periodontally-healthy controls (H, n=28). Furthermore, Hsp27 and Hsp60 levels were also measured longitudinally in 12 AgP patients at 6 time-points up to 3 months after treatment. Results: AgP patients had lower levels of Hsp27 compared to CP patients and healthy subjects (adjusted one-way ANOVA, p<0.001, followed by post-hoc Tukey HSD comparisons), while no differences in levels of Hsp60 or cytokines between the three groups were detected. In CP patients and H subjects the systemic Hsp27 levels correlated with Hsp60 (r=0.43, p<.001; r=0.59, p<0.001, respectively) and with pro-inflammatory cytokines TNF-α (r=0.48, p<.001; r=0.55, p<0.001, respectively) and IL-6 (r=0.44, p<0.01). However, no such correlations were detected in AgP cases. No consistent temporal patterns of changes of Hsp27 concentration were detected across AgP patients following periodontal treatment. Conclusions: This study provides the first evidence that Hsp27 may be differentially expressed and regulated in AgP patients as compared with CP patients and healthy individuals.

Type: Article
Title: Association between circulating levels of heat-shock protein 27 and aggressive periodontitis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s12192-018-0891-4
Publisher version: https://doi.org/10.1007/s12192-018-0891-4
Language: English
Additional information: Copyright © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Periodontitis, Stress-Proteins, Hsp27, Inflammation, Cytokines
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
URI: https://discovery.ucl.ac.uk/id/eprint/10045352
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